Chiral induction in covalent organic frameworks - Nature
WEBApr 3, 2018 · Here we demonstrate chiral COFs (CCOFs) can be crystallized from achiral organic precursors by chiral catalytic induction.
Bottom-up synthesis of chiral covalent organic frameworks and …
WEBJul 12, 2016 · Here we show a bottom-up strategy to construct chiral COFs and an in situ growth approach to fabricate chiral COF-bound capillary columns for chiral gas chromatography.
Chiral covalent organic frameworks: design, synthesis and …
WEBJul 29, 2020 · This review covers the recent advances in the field of chiral COFs (CCOFs), including their design principles and synthetic strategies, structural studies, and potential applications in asymmetric catalysis, enantioselective separation, and chiral recognition.
The effect of enantioselective chiral covalent organic frameworks …
WEBOct 1, 2022 · Chiral covalent organic frameworks are demonstrated to enable the docking of sacrificial electron donors via enantioselective combination, thereby improving oxidative half-reaction kinetics...
Covalent Organic Frameworks with Tunable Chirality for Chiral …
WEBFeb 28, 2024 · CCOF-9, distinguished by its unique C2 symmetric “armchair” tetrasubstituted pyrene conformation, exhibits the most pronounced chirality among these materials and serves as a solid-state host, enabling the enantioselective adsorption of racemic drugs with an enantiomeric excess (ee) of up to 97%.
Chiral covalent organic frameworks: design, synthesis and property ...
WEBJan 7, 2020 · (3) Chiral induction synthesis: synthesis of a homochiral COF from achiral organic precursors by chiral catalytic induction. Here we briefly discuss the synthetic conditions and synthetic strategies of CCOF powders ( Table 1 ).
Challenges and opportunities for chiral covalent organic …
WEBApr 30, 2022 · To date, there are three well-established synthetic strategies to construct CCOFs: (1) direct synthesis: using optically pure monomers as cross-linking building units to directly synthesise CCOFs; 19–25 (2) post-synthetic modification (PSM): reacting achiral parent COFs with chiral molecules to engender chirality via the post-synthetic ...
Stable hydrazone-linked chiral covalent organic frameworks: Synthesis ...
WEBJan 1, 2021 · The designed synthesis of chiral covalent organic frameworks (COFs) featuring intriguing properties is fairly scant and remains a daunting synthetic challenge. Here we develop a de novo synthesis of an enantiomeric pair of 2D hydroxyl-functionalized hydrazone-linked chiral COFs, (S)- and (R)-HthBta-OH COFs, using enantiopure 2,5-bis (2 ...
Divergent Synthesis of Chiral Covalent Organic Frameworks
WEBMay 15, 2019 · Constructed herein are four types of chiral COFs (CCOFs) from DBCBI by nucleophilic substitution, Suzuki coupling, and imine formation. The unique array of eight isoframework CCOFs allowed investigation of their catalytic performance and structure–activity relationship in an asymmetric amination …
Mixed-Linker Chiral 2D Covalent Organic Frameworks with …
WEBDec 26, 2023 · Covalent organic frameworks (COFs) have undergone extensive research as heterogeneous catalysts for a wide range of significant reactions, but they have not yet been investigated in the realm of electrochemical asymmetric catalysis, despite their recognition as an economical and sustainable strategy for producing enantiopure compounds. Here, we report a mixed-linker strategy to design ...
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