DNA condensation - Wikipedia
WEBDNA condensation refers to the process of compacting DNA molecules in vitro or in vivo. [1] Mechanistic details of DNA packing are essential for its functioning in the process of gene regulation in living systems.
Dynamic control of DNA condensation | Nature Communications
WEBMar 1, 2024 · We demonstrate reversible dissolution and growth of DNA condensates in the presence of specific DNA inputs, and we characterize the role of toehold domains, nanostar size, and nanostar valency.
The structure and intermolecular forces of DNA condensates
WEBMar 3, 2016 · Spontaneous assembly of DNA molecules into compact structures is ubiquitous in biological systems. Experiment has shown that polycations can turn electrostatic self-repulsion of DNA into attraction, yet the physical mechanism of DNA condensation has remained elusive.
DNA Condensation - an overview | ScienceDirect Topics
WEBDNA condensation refers to the process of compacting DNA molecules, which has significant implications for gene delivery and expression. This process involves overcoming unfavorable forces such as DNA bending, entropy of mixing, and electrostatic repulsion, typically through the use of multivalent cations.
A Comprehensive Biophysical Analysis of the Effect of DNA
WEBApr 10, 2019 · DNA condensation is a ubiquitous phenomenon in biology, yet the physical basis for it has remained elusive. Here, we have explored the mechanism of DNA condensation through the protamine-DNA...
DNA Condensation - an overview | ScienceDirect Topics
WEBDNA condensation is the main nuclear event in spermiogenesis leading to transcriptional silencing; this process requires histone replacement by protammine (P), a class of small basic protein.
Measuring condensation forces - Nature Methods
WEBSep 3, 2021 · Researchers use an in vitro assay in combination with a polymer model to study protein–DNA condensation and how condensates bring distant DNA elements into close proximity.
Condensed DNA: Condensing the concepts - ScienceDirect
WEBMay 1, 2011 · We will start with biological concepts arising from DNA packing in viruses, bacteria and eukaryotes, then proceed to DNA condensation in vitro and its theoretical modeling, and finally discuss the role of DNA condensation in the context of gene regulation in living systems and its potential biomedical applications.
DNA length tunes the fluidity of DNA-based condensates
WEBApr 6, 2021 · Mechanistically, DNA condensation can be driven by macromolecular crowding, multivalent cations, or positively charged proteins. At low DNA concentration, condensation triggers the conformational change of individual DNA molecules into a compacted state, with distinct morphologies.
Sequence-dependent DNA condensation as a driving force of DNA …
WEBOct 10, 2018 · By using constructs that combine elements of DNA and RNA structures, we establish the dominant role of methylation in determining the strength of DNA condensation. We also show that the strength of DNA condensation depends not only on nucleotide composition but also on their sequence arrangement.
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