Activation of AMPKα1 is essential for regulatory T cell ... - Nature
WEBNov 2, 2021 · Here, we report that mice with AMP-activated protein kinase alpha 1 (AMPKα1) globally knocked out spontaneously develop immune-mediated liver injury, with massive lymphocyte infiltration in the...
The T Cell Receptor Immune Repertoire Protects the Liver From ...
WEBDec 18, 2020 · The results from scRNA-seq and bulk immune repertoire sequencing (IR-seq) revealed an obvious decline in T cell receptor (TCR) clonotypes combined with shrinking VJ and VDJ segment usage, as well as lower complementarity-determining region 3 (CDR3) amino acid (AA) diversity from fibrotic liver.
Auto-aggressive CXCR6 + CD8 T cells cause liver immune ... - Nature
WEBMar 24, 2021 · Liver resident CD8 T cells have an essential role in immunopathology in a mouse model of nonalcoholic steatohepatitis, by becoming auto-aggressive following sequential transcriptional and ...
Diagnostic role of tests for T cell receptor (TCR) genes
WEBRepresentative flow cytometric T cell receptor β variable gene (TCRVB) profiles of a healthy control compared with a patient with T cell lymphoma. TCRVβ repertoire analysis was performed using triple colour analysis with CD3 in combination with two different TCRVβ antibodies for each tube.
Recent insights of T cell receptor-mediated signaling pathways for …
WEBMay 21, 2020 · T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility complex...
Recent insights of T cell receptor-mediated signaling pathways for …
WEBMay 21, 2020 · T cells develop from thymus-migrant hematopoietic lineage cells, particularly common lymphoid progenitors or lymphoid-primed multipotent progenitors derived from the bone marrow or the fetal liver 33,34.
Frontiers | Single Cell T Cell Receptor Sequencing: Techniques and ...
WEBJul 7, 2018 · TCRs are cell specific and represent a sort of “molecular tag” of T cells and have been widely studied to monitor the dynamics of T cells in terms of clonality and diversity in several contexts including lymphoid malignancies, infectious diseases, autoimmune diseases, and tumor immunology.
TCRαβ+ CD4-/CD8- "double negative" T cells in health and …
WEBAbstract. Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system.
Benchmarking of T cell receptor repertoire profiling methods …
WEBSep 7, 2020 · Monitoring the T cell receptor (TCR) repertoire in health and disease can provide key insights into adaptive immune responses, but the accuracy of current TCR sequencing (TCRseq) methods is...
Tcrd Rearrangement Redirects a Processive Tcra ... - Cell Press
WEBJun 6, 2017 · V (D)J recombination. Introduction. Vertebrate adaptive immune systems depend on variable, diversity, and joining (V [D]J) recombination to generate pools of diverse, clonally distributed antigen receptors (AgRs) on T and B lymphocytes.