Rams 0-2. Series record: 49ers lead 78-69-3. Last meeting: Rams beat 49ers 21-20 in Santa Clara, Calif. on Jan. 7. Last week: 49ers lost to Minnesota 23-17; Rams lost to Arizona 41-10. 49ers offense: ...

The 49ers and star running back Christian McCaffrey already were a match made in heaven -- purely for reasons on the field.

The 49ers managed to avoid punishment for the apparent concealment of running back Christian McCaffrey’s true injury status on Monday, in large part because the NFL doesn’t need to be telling the ...

SANTA CLARA, Calif. (AP) — San Francisco 49ers safety Talanoa Hufanga was a full participant in practice for the first time since tearing a ligament in his knee last November and could be set to ...

The San Francisco 49ers are trying to do the near-impossible: go from Super Bowl runners-up to Super Bowl champions. Though the 1970 Dallas Cowboys, 1971 Miami Dolphins, and 2017 New England ...

LATEST Sept. 14, 10:30 a.m. The San Francisco 49ers are placing Christian McCaffrey on injured reserve on Saturday, according to multiple reports. ESPN’s Adam Schefter and NFL Network’s Ian ...

Colin Cowherd unveils his Week 3 Herd Hierarchy, including the Los Angeles Chargers leaping to the Top 3, New Orleans Saints making the cut and the San Francisco 49ers dropping to the bottom 5.

The season isn't over for the 49ers despite their upset loss to the Vikings. In fact, there is a benefit to it. Here is how. Losing to the Minnesota Vikings was pitiful for the San Francisco 49ers.

Jefferson caught it in stride just across midfield after it soared 55 yards in the air and ran diagonally toward the 49ers sideline, before stutter-stepping at the 32 and veering the opposite ...

Minnesota Vikings wide receiver Justin Jefferson suffered an apparent leg injury in the second half of his team's Week 2 game against the San Francisco 49ers. Jefferson was banged-up while ...