The San Francisco 49ers and Los Angeles Rams have aspirations of winning the NFC West and making another Super Bowl run, but ...

The 49ers are without Christian McCaffrey, Deebo Samuel and maybe George Kittle, while the Rams won’t have top receivers Cooper Kupp and Puka Nacua.

The San Francisco 49ers could be without another key offensive player this week after All-Pro tight end George Kittle missed ...

Injuries stacked up quickly for the San Francisco 49ers leading up to their Week 3 showdown with the Los Angeles Rams.

Bruce Marshall is a handicapper for CBS Sportsline. He provides the Review-Journal with NFL betting notes and trends.

Brown and Odum allowed Justin Jefferson to get behind them for a 97-yard touchdown pass from Sam Darnold. Both are considered ...

Soft-tissue injuries are often prevalent early in the NFL season because there is less contact during training camp and ...

The Niners will perhaps be without arguably their three most important offensive weapons, sidelined stars Christian McCaffrey ...

If Ward is unable to go, all signs point to rookie second-round pick Renardo Green getting the start as the 49ers’ nickel ...

The spread has moved one point in the Rams’ direction since Monday, likely because of the 49ers’ recent injury news ...

Here's everything you need to know for Week 3 NFL games. Which teams will win? Who are the X factors, and which storylines ...

The first two weeks of the NFL season delivered plenty of unexpected chaos. Many were quick to overreact to Week 1 games, leading to several upsets in Week 2. C ...