The 49ers and star running back Christian McCaffrey already were a match made in heaven -- purely for reasons on the field.

Rams 0-2. Series record: 49ers lead 78-69-3. Last meeting: Rams beat 49ers 21-20 in Santa Clara, Calif. on Jan. 7. Last week: 49ers lost to Minnesota 23-17; Rams lost to Arizona 41-10. 49ers offense: ...

Where did the Rams go wrong? Are the Rams that bad? Injuries already taking a toll? Did they have the bad luck of running ...

The 17-year-old suspect accused of shooting 49ers rookie Ricky Pearsall during an attempted robbery in San Francisco last ...

SANTA CLARA, Calif. (AP) — San Francisco 49ers safety Talanoa Hufanga was a full participant in practice for the first time since tearing a ligament in his knee last November and could be set to ...

Mason ran for 147 yards and a touchdown in place of the injured Christian McCaffrey and the 49ers spoiled Rodgers’ comeback game with a 32-19 victory over the New York Jets on Monday night. The former ...

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In the offseason, the Vikings went after defensive reinforcements as soon as they could. A deeper defense has allowed the third-fewest points in the NFL through two games.

SAN FRANCISCO (AP) — A 17-year-old high school senior charged with attempted murder in the daytime weekend shooting of San Francisco 49ers rookie receiver Ricky Pearsall was arraigned in juvenile ...

Los Angeles Dodgers superstar Shohei Ohtani etched his name in Major League Baseball history on Thursday, becoming the ...

Turnover differential: Jets minus-6; 49ers plus-10.

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