Before looking at SportsbookWire staff's Week 3 NFL picks, here are the against-the-spread (ATS) and Over/Under (O/U) leaders, according to Teamrankings.com. Six teams are 2-0 ATS. They are the Arizona Cardinals (1-1 straight-up record),

Here's everything you need to know for Week 3 NFL games. Which teams will win? Who are the X factors, and which storylines matter most?

Last week was a rough one for favourites in the NFL, as each of the top three ATS faves took straight-up losses. But our staff is looking for that storyline